Gas Gangrene Toxin



Gas gangrene toxin (GGT) is a toxin produced by the bacterium Clostridium. It is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It is a phospholipase. The images at the left and at the right correspond to one representative GGT, i.e. the crystal structure of Gas gangrene toxin from Clostridium perfringens (2wxt).

3D Structures of Gas gangrene toxin
2wxt, 1qm6, 1ca1 - CpGGT – Clostridium perfringens

2wy6, 2wxu – CpGGT (mutant)

1qmd - CpGGT + Ca++

1olp - GGT – Clostridium absonum